The supercomputer is built with the Fujitsu A64FX microprocessor. This CPU is based on the ARM version 8.2A processor architecture, and adopts the Scalable Vector Extensions for supercomputers. Fugaku was aimed to be about 100 times more powerful than the K computer (i.e. a performance target of 1 exaFLOPS) and have a high level of practicability in the world. Fugaku uses 158,976 A64FX CPUs joined together using Fujitsu's propietary torus fusion interconnect.
The final reported performance of Fugaku is a Rpeak of 0.54 exaFLOPS in the FP64 used by the TOP500.
Virus receptors are key components of the early events involved in cell infection. The examples outlined above should illustrate that the definition of receptors acting solely as attachment molecules is overly simplistic. In addition to attachment, receptors also actively contribute to entry by initiating conformational changes in the virus that lead to uncoating. In addition, they provide mechanisms for internalization – which increasingly appear to involve signaling events that occur upon receptor binding – in which the virus may subvert a natural receptor cycling process. Furthermore, the identification of virus receptors contributes significantly to our understanding of host, tissue, and cell tropism, and helps explain aspects of virus pathogenesis. The selected bibliography provides further examples illustrating aspects of virus receptor identification and function.